FLT4 Antibody – Cat. #: CSB-PA277523 Gene Bio Systems

Size :100ul

Clone Number:

Aliases:EC 2.7.10.1 antibody; flt 4 antibody; FLT-4 antibody; FLT4 antibody; FLT41 antibody; Fms related tyrosine kinase 4 antibody; Fms-like tyrosine kinase 4 antibody; LMPH1A antibody; PCL antibody; Soluble VEGFR3 variant 1 antibody; Soluble VEGFR3 variant 2 antibody; Soluble VEGFR3 variant 3 antibody; Tyrosine protein kinase receptor FLT4 antibody; Tyrosine-protein kinase receptor FLT4 antibody; Vascular endothelial growth factor receptor 3 antibody; Vascular endothelial growth factor receptor 3 precursor antibody; VEGF R3 antibody; VEGFR 3 antibody; VEGFR-3 antibody; VEGFR3 antibody; VGFR3_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P35916

Immunogen:Peptide sequence around aa.1279~1283 (L-A-S-E-E) derived from Human VEGFR-3.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200

Background:

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at ‘Thr-183’ and ‘Tyr-185’, and of AKT1 at ‘Ser-473’.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FLT4

Research Areas:Epigenetics and Nuclear Signaling;Cancer?Cardiovascular;Signal transduction