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FLT4 Antibody, Biotin conjugated – Cat. #: CSB-PA07539D0Rb Gene Bio Systems

Original price was: $ 431,60.Current price is: $ 129,48.

SKU: mode_6913784774756 Category: Uncategorized Tag: PRIMARY ANTIBODIES

Description
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Size :50ug

Clone Number:

Aliases:EC 2.7.10.1 antibody; flt 4 antibody; FLT-4 antibody; FLT4 antibody; FLT41 antibody; Fms related tyrosine kinase 4 antibody; Fms-like tyrosine kinase 4 antibody; LMPH1A antibody; PCL antibody; Soluble VEGFR3 variant 1 antibody; Soluble VEGFR3 variant 2 antibody; Soluble VEGFR3 variant 3 antibody; Tyrosine protein kinase receptor FLT4 antibody; Tyrosine-protein kinase receptor FLT4 antibody; Vascular endothelial growth factor receptor 3 antibody; Vascular endothelial growth factor receptor 3 precursor antibody; VEGF R3 antibody; VEGFR 3 antibody; VEGFR-3 antibody; VEGFR3 antibody; VGFR3_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P35916

Immunogen:Recombinant Human Vascular endothelial growth factor receptor 3 protein (1112-1329AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at ‘Thr-183’ and ‘Tyr-185’, and of AKT1 at ‘Ser-473’.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FLT4

Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Signal transduction

Prompt Shipping and professional packaging

Because of our long-standing partnership in a long-standing partnership with UPS, FedEx, DHL and a variety of other leading global carriers, we can provide a variety of shipping options. Our warehouse staff are highly trained to package your goods exactly as per the specifications we offer. Your goods are thoroughly checked and securely secured prior to shipment. We deliver to thousands of customers every day from all over the world. This shows that we're committed to being the largest retailer online in the world. The warehouses and centers of distribution are situated in Europe, as well as the USA.

Note: Orders that contain more than one item are assigned a particular processing time, based on the individual item.

Prior to shipping We will inspect thoroughly the items you have ordered. The majority of orders will be sent within 48 hours. It is expected that delivery will take between three and seven days.

Returns

The inventory is always changing and we do not completely manage it due to the fact that several parties are involved, including our factory and warehouse. The actual stock levels can fluctuate at any moment. Be aware that it is possible that your order will run out of stock even after you've placed your order.

Our policy runs for 30 days. However, if 30 days have passed from the date you purchased the item, we cannot give you a refund or exchange.

To be eligible for a return, your product must be unopened and in the same condition as when you received it. The item must be in its original packaging.

FLT4 Antibody, Biotin conjugated – Cat. #: CSB-PA07539D0Rb Gene Bio Systems

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