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FYN (Ab-530) Antibody – Cat. #: CSB-PA914183 Gene Bio Systems

Original price was: $ 772,20.Current price is: $ 231,66.

SKU: mode_6912100204644 Category: Uncategorized Tag: PRIMARY ANTIBODIES

Description
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Size :100ul

Clone Number:

Aliases:C syn protooncogene antibody; Fyn antibody; FYN oncogene related to SRC FGR YES antibody; FYN_HUMAN antibody; OKT3 induced calcium influx regulator antibody; P59 FYN antibody; p59-Fyn antibody; Protein tyrosine kinase fyn antibody; Proto oncogene tyrosine protein kinase fyn antibody; Proto-oncogene c-Fyn antibody; Proto-oncogene Syn antibody; Protooncogene Syn antibody; SLK antibody; Src like kinase antibody; Src yes related novel gene antibody; Src-like kinase antibody; Src/yes related novel antibody; SYN antibody; Tyrosine kinase p59fyn T antibody; Tyrosine kinase p59fyn(T) antibody; Tyrosine-protein kinase Fyn antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P06241

Immunogen:Synthesized non-phosphopeptide derived from Human Fyn around the phosphorylation site of tyrosine 530 (P-Q-Y(p)-Q-P).

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

Kawakami T., Mol. Cell. Biol. 6:4195-4201(1986).
Semba K., Proc. Natl. Acad. Sci. U.S.A. 83:5459-5463(1986).
Rigley K., J. Immunol. 154:1136-1145(1995)

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FYN

Research Areas:Neuroscience?Cancer;Signal transduction

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Returns

The inventory is always changing and we do not completely manage it due to the fact that several parties are involved, including our factory and warehouse. The actual stock levels can fluctuate at any moment. Be aware that it is possible that your order will run out of stock even after you've placed your order.

Our policy runs for 30 days. However, if 30 days have passed from the date you purchased the item, we cannot give you a refund or exchange.

To be eligible for a return, your product must be unopened and in the same condition as when you received it. The item must be in its original packaging.

FYN (Ab-530) Antibody – Cat. #: CSB-PA914183 Gene Bio Systems

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