Size :50ug
Clone Number:
Aliases:CD 350 antibody; CD 350 antigen antibody; CD350 antibody; Frizzled (Drosophila) homolog 10 antibody; Frizzled-10 antibody; FZ 10 antibody; Fz-10 antibody; FZ10 antibody; FZD 10 antibody; FZD10 antibody; FZD10_HUMAN antibody; FzE 7 antibody; FzE7 antibody; hFz 10 antibody; hFz10 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q9ULW2
Immunogen:Recombinant Human Frizzled-10 protein (125-225AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:
Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:FZD10
Research Areas:Epigenetics and Nuclear Signaling; Signal transduction; Stem cells