Size :50ug
Clone Number:
Aliases:GRB14Growth factor receptor-bound protein 14 antibody; GRB14 adapter protein antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q14449
Immunogen:Recombinant Human Growth factor receptor-bound protein 14 protein (294-397AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:GRB14
Research Areas:Signal transduction