Size :50ul
Clone Number:
Aliases:Histone H2AX (H2a/x) (Histone H2A.X), H2AFX, H2AX
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P16104
Immunogen:Synthesized peptide derived from Human Histone H2AX protein (130-142aa)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:10-1:100
Background:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen Affinity Purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:H2AFX
Research Areas:Epigenetics and Nuclear Signaling