CHMP1A Antibody, Biotin conjugated – Cat. #: CSB-PA881032LD01HU Gene Bio Systems

Size :50ug

Clone Number:

Aliases:Charged multivesicular body protein 1a antibody; CHM1A_HUMAN antibody; CHMP1a antibody; Chromatin modifying protein 1a antibody; Chromatin-modifying protein 1a antibody; hVps46 1 antibody; hVps46-1 antibody; KIAA0047 antibody; Metalloprotease 1 antibody; PCOLN3 antibody; Procollagen (type III) N endopeptidase antibody; PRSM1 antibody; Vacuolar protein sorting 46 1 antibody; Vacuolar protein sorting-associated protein 46-1 antibody; Vps46 1 antibody; Vps46-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9HD42

Immunogen:Recombinant Human Charged multivesicular body protein 1a protein (1-196AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:CHMP1A

Research Areas:Cancer; Cell biology; Signal transduction