Size :50ug
Clone Number:
Aliases:COP9 homolog antibody; COP9 signalosome complex subunit 8 antibody; COP9 signalosome subunit 8 antibody; Cops8 antibody; CSN8 antibody; CSN8_HUMAN antibody; hCOP9 antibody; JAB1 containing signalosome subunit 8 antibody; JAB1-containing signalosome subunit 8 antibody; SGN8 antibody; Signalosome subunit 8 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q99627
Immunogen:Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:COPS8
Research Areas:Cell biology; Developmental biology; Immunology; Signal transduction; Stem cells