Size :50ug
Clone Number:
Aliases:DAD 1 antibody; DAD-1 antibody; dad1 antibody; DAD1_HUMAN antibody; Defender against cell death 1 antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase subunit DAD1 antibody; Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit DAD1 antibody; Oligosaccharyl transferase subunit DAD1 antibody; OST 2 antibody; OST2 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P61803
Immunogen:Recombinant Human Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit DAD1 protein (1-113AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:
Background:Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc3Man9GlcNAc2 in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853).
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DAD1
Research Areas:Cell biology