Size:100ug
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Immunogen:dickkopf homolog 1
Synonyms:Dickkopf 1, Dickkopf related protein 1, DKK 1, DKK1, hDkk 1, SK
Observed MW:30-35 kDa
Uniprot ID:O94907
Reactivity:Human, Mouse, Rat
Tested Application:ELISA, WB, IF, IHC
Recommended dilution:WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100
Gene ID:22943
Research Area:Signal Transduction, Developmental biology