Size :100ul
Clone Number:
Aliases:DOK4Docking protein 4 antibody; Downstream of tyrosine kinase 4 antibody; Insulin receptor substrate 5 antibody; IRS-5 antibody; IRS5 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q8TEW6
Immunogen:Synthesized peptide derived from internal of Human DOK4.
Raised in:Rabbit
Species Reactivity:Human, Mouse
Tested Applications:ELISA, WB; WB:1:500-1:3000
Background:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway By similarity. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Favre C., Genes Immun. 4:40-45(2003).
Cai D., J. Biol. Chem. 278:25323-25330(2003).
Loftus B.J., Genomics 60:295-308(1999).
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DOK4
Research Areas:Neuroscience;Signal transduction