Size :100ul
Clone Number:
Aliases:DTBP1_HUMAN antibody; DTNBP1 antibody; Dysbindin antibody; Dysbindin-1 antibody; Dystrobrevin binding protein 1 antibody; Dystrobrevin-binding protein 1 antibody; Hermansky Pudlak syndrome 7 protein antibody; Hermansky-Pudlak syndrome 7 protein antibody; HPS7 antibody; HPS7 protein antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q96EV8
Immunogen:Recombinant protein of Human DTNBP1
Raised in:Rabbit
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200
Background:Dysbindin, or dystrobrevin-binding protein 1, is a coiled-coil-containing protein expressed in muscle and brain that was identified as a binding partner of dystrobrevin. Dysbindin upregulates expression of the pre-synaptic proteins SNAP25 and synapsin I, thereby increasing glutamate release and promoting neuronal viability through Akt signaling. In particular, Akt phosphorylation is suppressed with downregulation of dysbindin and increased with upregulation of dysbindin. A nonsense mutation of dysbindin causes Hermansky-Pudlak disease, an autosomal recessive disorder characterized by lysosomal storage defects and prolonged bleeding. Genetic variation in the gene encoding dysbindin is strongly associated with schizophrenia and protein levels are reduced in the prefrontal cortex, midbrain and hippocampus of brains from patients with schizophrenia.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Affinity purification
Conjugate:Non-conjugated
Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DTNBP1
Research Areas:Neuroscience