Size :100ul
Clone Number:
Aliases:4E-BP1 antibody; 4EBP1 antibody; 4EBP1_HUMAN antibody; BP 1 antibody; eIF4E binding protein 1 antibody; eIF4E-binding protein 1 antibody; Eif4ebp1 antibody; Eukaryotic translation initiation factor 4E-binding protein 1 antibody; PHAS-I antibody; PHASI antibody; Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q13541
Immunogen:Synthesized non-phosphopeptide derived from Human 4E-BP1 around the phosphorylation site of serine 65 (R-N-S(p)-P-V).
Raised in:Rabbit
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100
Background:Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Anne-Claude Gingras, Genes & Dev., Jun 1999; 13: 1422.
Guangming Liu, J. Biol. Chem., Mar 2002; 277: 8810 – 8816.
Ya-Ping Jiang, J. Biol. Chem., Mar 2001; 276: 10943 – 10951.
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:EIF4EBP1
Research Areas:Epigenetics and Nuclear Signaling;Metabolism