Size :50ug
Clone Number:
Aliases:ACKR1 antibody; Atypical chemokine receptor 1 antibody; CCBP1 antibody; CD234 antibody; DARC antibody; Dfy antibody; Duffy antigen/chemokine receptor antibody; duffy blood group antibody; Duffy blood group antigen antibody; Duffy blood group chemokine receptor antibody; DUFFY_HUMAN antibody; FY antibody; Fy glycoprotein antibody; Glycoprotein D antibody; GPD antibody; GpFy antibody; Plasmodium vivax receptor antibody; WBCQ1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q16570
Immunogen:Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:
Background:Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ACKR1
Research Areas:Cardiovascular; Immunology; Microbiology; Signal transduction