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ATF4 antibody , Cat. # FNab00663 Gene Bio Systems

Original price was: $ 535,00.Current price is: $ 160,50.

SKU: mode_6918465683556 Category: Uncategorized Tag: PRIMARY ANTIBODIES

Description
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Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:0B11

Isotype:IgG1

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5′-GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).

Immunogen:activating transcription factor 4

Synonyms:ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB

Observed MW:50-58 kDa

Uniprot ID:P18848

Reactivity:Human, Mouse

Tested Application:ELISA, IHC, WB, IF

Recommended dilution:WB: 1:1000-1:2000; IHC: 1:50-1:300; IF: 1:20-1:100

Gene ID:468

Research Area:Neuroscience, Epigenetics, Metabolism, Developmental biology

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Note: Orders that contain more than one item are assigned a particular processing time, based on the individual item.

Prior to shipping We will inspect thoroughly the items you have ordered. The majority of orders will be sent within 48 hours. It is expected that delivery will take between three and seven days.

Returns

The inventory is always changing and we do not completely manage it due to the fact that several parties are involved, including our factory and warehouse. The actual stock levels can fluctuate at any moment. Be aware that it is possible that your order will run out of stock even after you've placed your order.

Our policy runs for 30 days. However, if 30 days have passed from the date you purchased the item, we cannot give you a refund or exchange.

To be eligible for a return, your product must be unopened and in the same condition as when you received it. The item must be in its original packaging.

ATF4 antibody , Cat. # FNab00663 Gene Bio Systems

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