Size:100ug
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Immunogen:claspin homolog(Xenopus laevis)
Synonyms:
Observed MW:240 kDa
Uniprot ID:Q9HAW4
Reactivity:Human
Tested Application:ELISA, WB, IF, IP
Recommended dilution:WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200
Gene ID:63967
Research Area: