Size :50ug
Clone Number:
Aliases:Canstatin antibody; CO4A2_HUMAN antibody; COL4A 2 antibody; Col4a2 antibody; Collagen alpha 2(IV) chain antibody; Collagen; type IV; alpha 2 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P08572
Immunogen:Recombinant Human Collagen alpha-2(IV) chain protein (1493-1712AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Background:Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a \’chicken-wire\’ meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:COL4A2
Research Areas:Cardiovascular; Signal transduction