Size :50ul
Clone Number:
Aliases:Alpha 3 type IV collagen antibody; Alpha3 type IV collagen antibody; CO4A3_HUMAN antibody; COL4A 3 antibody; Col4a3 antibody; Collagen alpha 3(IV) chain antibody; Collagen IV alpha 3 polypeptide antibody; Collagen type IV alpha 3 (Goodpasture antigen) antibody; Collagen type IV alpha 3 antibody; Collagen type IV alpha 3 chain antibody; Goodpasture antigen antibody; OTTHUMP00000195044 antibody; Tumstatin antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q01955
Immunogen:Synthetic peptide of Human COL4A3
Raised in:Rabbit
Species Reactivity:Human, Mouse
Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100
Background:Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjugate:Non-conjugated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:COL4A3
Research Areas:Cancer;Immunology;Signal transduction