Size:100ug
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).
Immunogen:chemokine(C-X3-C motif) ligand 1
Synonyms:FKN, NTT, SCYD1
Observed MW:90-100 kDa
Uniprot ID:P78423
Reactivity:Human, Mouse, Rat
Tested Application:ELISA, WB, IHC
Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200
Gene ID:6376
Research Area:Stem Cells, Immunology, Signal Transduction