Size:100ug
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins(IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.This antibody recognizes all the three isoforms of DIABLO.
Immunogen:diablo homolog(Drosophila)
Synonyms:DIABLO, Diablo homolog, mitochondrial, DIABLO S, SMAC, SMAC3
Observed MW:20 kDa
Uniprot ID:Q9NR28
Reactivity:Human, Mouse, Rat
Tested Application:ELISA, WB, IHC, IP
Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200
Gene ID:56616
Research Area:Cancer