Size :50ul
Clone Number:
Aliases:5DII antibody; D2 antibody; Deiodinase, iodothyronine, type II antibody; DIO2 antibody; DIOII antibody; EC 1.97.1.10 antibody; IOD2_HUMAN antibody; ITDI2 antibody; SelY antibody; Thyroxine deiodinase, type II antibody; TXDI2 antibody; Type 2 DI antibody; Type 2 iodothyronine deiodinase antibody; Type II 5′ deiodinase antibody; Type II iodothyronine deiodinase antibody; Type-II 5”-deiodinase antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q92813
Immunogen:Synthetic peptide of Human DIO2
Raised in:Rabbit
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB; ELISA:1:1000-1:2000, WB:1:200-1:1000
Background:The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3′,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3′ UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjugate:Non-conjugated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DIO2
Research Areas:Others