Size :50ug
Clone Number:
Aliases:DTBP1_HUMAN antibody; DTNBP1 antibody; Dysbindin antibody; Dysbindin-1 antibody; Dystrobrevin binding protein 1 antibody; Dystrobrevin-binding protein 1 antibody; Hermansky Pudlak syndrome 7 protein antibody; Hermansky-Pudlak syndrome 7 protein antibody; HPS7 antibody; HPS7 protein antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q96EV8
Immunogen:Recombinant Human Dysbindin protein (258-351AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200
Background:Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DTNBP1
Research Areas:Neuroscience