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EFNA1 Antibody – Cat. #: CSB-PA551061 Gene Bio Systems

Original price was: $ 772,20.Current price is: $ 231,66.

SKU: mode_6912191758436 Category: Uncategorized Tag: PRIMARY ANTIBODIES

Description
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Size :100ul

Clone Number:

Aliases:B61 antibody; ECKLG antibody; EFL 1 antibody; EFL1 antibody; EFNA 1 antibody; Efna1 antibody; EFNA1_HUMAN antibody; EPH related receptor tyrosine kinase ligand 1 antibody; EPH-related receptor tyrosine kinase ligand 1 antibody; Ephrin-A1 antibody; Ephrin-A1, secreted form antibody; EphrinA1 antibody; EPLG 1 antibody; EPLG1 antibody; Immediate early response protein B61 antibody; LERK 1 antibody; LERK-1 antibody; LERK1 antibody; Ligand of eph related kinase 1 antibody; OTTHUMP00000033242 antibody; OTTHUMP00000033271 antibody; secreted form antibody; TNF alpha-induced protein 4 antibody; TNFAIP 4 antibody; TNFAIP4 antibody; Tumor necrosis factor alpha induced protein 4 antibody; Tumor necrosis factor alpha-induced protein 4 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P20827

Immunogen:Synthesized peptide derived from internal of Human EFNA1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IF; WB:1:500-1:3000, IF:1:100-1:500

Background:Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Holzman L.B., Mol. Cell. Biol. 10:5830-5838(1990).
Gregory S.G., Nature 441:315-321(2006).
Zhang Z., Protein Sci. 13:2819-2824(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:EFNA1

Research Areas:Neuroscience;Cardiovascular;Signal transduction

Prompt Shipping and professional packaging

Because of our long-standing partnership in a long-standing partnership with UPS, FedEx, DHL and a variety of other leading global carriers, we can provide a variety of shipping options. Our warehouse staff are highly trained to package your goods exactly as per the specifications we offer. Your goods are thoroughly checked and securely secured prior to shipment. We deliver to thousands of customers every day from all over the world. This shows that we're committed to being the largest retailer online in the world. The warehouses and centers of distribution are situated in Europe, as well as the USA.

Note: Orders that contain more than one item are assigned a particular processing time, based on the individual item.

Prior to shipping We will inspect thoroughly the items you have ordered. The majority of orders will be sent within 48 hours. It is expected that delivery will take between three and seven days.

Returns

The inventory is always changing and we do not completely manage it due to the fact that several parties are involved, including our factory and warehouse. The actual stock levels can fluctuate at any moment. Be aware that it is possible that your order will run out of stock even after you've placed your order.

Our policy runs for 30 days. However, if 30 days have passed from the date you purchased the item, we cannot give you a refund or exchange.

To be eligible for a return, your product must be unopened and in the same condition as when you received it. The item must be in its original packaging.

EFNA1 Antibody – Cat. #: CSB-PA551061 Gene Bio Systems

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