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FBXW7 Antibody, HRP conjugated – Cat. #: CSB-PA822163LB01HU Gene Bio Systems

Original price was: $ 431,60.Current price is: $ 129,48.

SKU: mode_6914027782244 Category: Uncategorized Tag: PRIMARY ANTIBODIES

Description
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Size :50ug

Clone Number:

Aliases:AGO antibody; Archipelago antibody; Archipelago homolog antibody; Archipelago, Drosophila, homolog of antibody; CDC4 antibody; CDC4, S.cerevisiae, homolog of antibody; DKFZp686F23254 antibody; F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody; F box and WD 40 domain protein 7 antibody; F box and WD repeat domain containing 7 antibody; F box protein FBW7 antibody; F box protein FBX30 antibody; F box protein SEL 10 antibody; F box protein SEL10 antibody; F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody; F-box and WD-40 domain-containing protein 7 antibody; F-box protein FBX30 antibody; F-box/WD repeat-containing protein 7 antibody; FBW6 antibody; FBW7 antibody; FBX30 antibody; FBXO30 antibody; FBXW6 antibody; FBXW7 antibody; FBXW7_HUMAN antibody; FLJ16457 antibody; hAgo antibody; hCdc4 antibody; Homolog of C elegans sel 10 antibody; Homolog of C.elegans sel10 antibody; SEL 10 antibody; SEL-10 antibody; SEL10 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q969H0

Immunogen:Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FBXW7

Research Areas:Cancer; Cell biology

Prompt Shipping and professional packaging

Because of our long-standing partnership in a long-standing partnership with UPS, FedEx, DHL and a variety of other leading global carriers, we can provide a variety of shipping options. Our warehouse staff are highly trained to package your goods exactly as per the specifications we offer. Your goods are thoroughly checked and securely secured prior to shipment. We deliver to thousands of customers every day from all over the world. This shows that we're committed to being the largest retailer online in the world. The warehouses and centers of distribution are situated in Europe, as well as the USA.

Note: Orders that contain more than one item are assigned a particular processing time, based on the individual item.

Prior to shipping We will inspect thoroughly the items you have ordered. The majority of orders will be sent within 48 hours. It is expected that delivery will take between three and seven days.

Returns

The inventory is always changing and we do not completely manage it due to the fact that several parties are involved, including our factory and warehouse. The actual stock levels can fluctuate at any moment. Be aware that it is possible that your order will run out of stock even after you've placed your order.

Our policy runs for 30 days. However, if 30 days have passed from the date you purchased the item, we cannot give you a refund or exchange.

To be eligible for a return, your product must be unopened and in the same condition as when you received it. The item must be in its original packaging.

FBXW7 Antibody, HRP conjugated – Cat. #: CSB-PA822163LB01HU Gene Bio Systems

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