Size :50ug
Clone Number:
Aliases:CD307c antibody; Fc receptor homolog 3 antibody; Fc receptor-like protein 3 antibody; FcR-like protein 3 antibody; FcRH3 antibody; FcRL3 antibody; FCRL3_HUMAN antibody; hIFGP3 antibody; IFGP family protein 3 antibody; IFGP3 antibody; Immune receptor translocation-associated protein 3 antibody; Immunoglobulin superfamily receptor translocation associated protein 3 antibody; IRTA3 antibody; SH2 domain-containing phosphatase anchor protein 2 antibody; SPAP2 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q96P31
Immunogen:Recombinant Human Fc receptor-like protein 3 protein (122-222AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275).
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:FCRL3
Research Areas:Immunology