Size :50ug
Clone Number:
Aliases:38 kDa FK506-binding protein antibody; 38 kDa FKBP antibody; 38kDa antibody; FK506 binding protein 8 antibody; FK506 binding protein 8, 38kDa antibody; FK506 binding protein, 38kDa antibody; FK506-binding protein 8 antibody; FKBP 38 antibody; FKBP-38 antibody; FKBP-8 antibody; Fkbp8 antibody; FKBP8_HUMAN antibody; FKBPR38 antibody; hFKBP38 antibody; Peptidyl-prolyl cis-trans isomerase FKBP8 antibody; PPIase FKBP8 antibody; Rotamase antibody; Sam11 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q14318
Immunogen:Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP8 protein (58-190AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:
Background:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:FKBP8
Research Areas:Cell biology; Signal transduction