Size :100ul
Clone Number:
Aliases:Activator protein 1 antibody; AP 1 antibody; C FOS antibody; Cellular oncogene c fos antibody; Cellular oncogene fos antibody; FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody; FBJ murine osteosarcoma viral oncogene homolog antibody; FBJ murine osteosarcoma viral v fos oncogene homolog antibody; FBJ Osteosarcoma Virus antibody; FOS antibody; FOS protein antibody; FOS_HUMAN antibody; G0 G1 switch regulatory protein 7 antibody; G0/G1 switch regulatory protein 7 antibody; G0S7 antibody; Oncogene FOS antibody; p55 antibody; proto oncogene c Fos antibody; Proto oncogene protein c fos antibody; Proto-oncogene c-Fos antibody; v fos FBJ murine osteosarcoma viral oncogene homolog antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P01100
Immunogen:Synthesized non-phosphopeptide derived from Human FOS around the phosphorylation site of threonine 232 (V-A-T(p)-P-E).
Raised in:Rabbit
Species Reactivity:Human, Mouse
Tested Applications:ELISA, WB; WB:1:500-1:3000
Background:Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
van Straaten F., Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).
Hai T., Genes Dev. 3:2083-2090(1989).
Heilig R., Nature 421:601-607(2003).
Clonality:Polyclonal
Isotype:IgG
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:FOS
Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer