Size :50ug
Clone Number:
Aliases:Hipk 1 antibody; Hipk1 antibody; HIPK1_HUMAN antibody; Homeodomain interacting protein kinase 1 antibody; Homeodomain interacting protein kinase 1 like protein antibody; Homeodomain-interacting protein kinase 1 antibody; Myak antibody; Nbak 2 antibody; Nbak2 antibody; Nuclear body associated kinase 2 antibody; Nuclear body associated kinase 2b antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q86Z02
Immunogen:Recombinant Human Homeodomain-interacting protein kinase 1 protein (1007-1151AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:HRP
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:HIPK1
Research Areas:Epigenetics and Nuclear Signaling; Signal transduction